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A commonly sought after disorder in allopathic clinical practice, these disorder assume enormous proportions. As a rule of thumb, any drug ingested (oral, inhaled, injected etc…) can cause eruptions over skin and mucous membrane (eyes, nose, oral cavity, genitals and anal canal). The lesions (rashes) can be seen within few hours to several days after the first dose of the offending drug. Prompt withdrawal of these drugs should clear these rashes to some extent. But few rashes require medical management. Any drug rash should be reported to a clinician, for judging the severity and extent of rash. Few rashes can be detrimental to life, like Steven Johnson Syndrome and Toxic Epidermal Necrolysis.